Delineation of the functional capacity of human neonatal lymphocytes.

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Delineation of the functional capacity of human neonatal lymphocytes.

Neonatal T cell-B cell collaboration was investigated utilizing a system of T cell-dependent polyclonal B cell activation and Ig secretion. In this system, T cells activated by immobilized anti-CD3 provide a potent stimulus for Ig production by adult lymphocytes. By contrast, anti-CD3 stimulation of cord blood lymphocytes generated minimal numbers of Ig-secreting cells. Ig production by neonata...

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ژورنال

عنوان ژورنال: Journal of Clinical Investigation

سال: 1991

ISSN: 0021-9738

DOI: 10.1172/jci115029